tag:blogger.com,1999:blog-1474751880645498536.post6864408315031179818..comments2023-10-10T10:14:36.340-04:00Comments on Medical Evidence Blog: Out to Lunch: Nutrition and Supplementation in Critical IllnessScott K. Aberegg, M.D., M.P.H.http://www.blogger.com/profile/17564774546019869201noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-1474751880645498536.post-68236145013317077892013-12-14T14:35:16.748-05:002013-12-14T14:35:16.748-05:00http://www.nytimes.com/2013/06/09/opinion/sunday/d...http://www.nytimes.com/2013/06/09/opinion/sunday/dont-take-your-vitamins.html?pagewanted=printScott K. Aberegg, M.D., M.P.H.https://www.blogger.com/profile/17564774546019869201noreply@blogger.comtag:blogger.com,1999:blog-1474751880645498536.post-31410000277567357982013-05-01T22:18:29.255-04:002013-05-01T22:18:29.255-04:00Well written Scott. What was demonstrated, yet aga...Well written Scott. What was demonstrated, yet again, is that "normalisation" of a "deficiency" is ineffective and possibly harmful( although like you I am struggling to find a mechanism to explain why glutamine would produce a 5% increase in absolute mortality). I've had influenza too and agree anorexia is very much an adaptive response Craig Frenchhttps://www.blogger.com/profile/12434747553779946554noreply@blogger.comtag:blogger.com,1999:blog-1474751880645498536.post-15498745523983912392013-04-18T06:04:01.846-04:002013-04-18T06:04:01.846-04:00Scott. Appreciate your long term blogging as a med...Scott. Appreciate your long term blogging as a medical specialist and statistical posts. In reference to http://cancerres.aacrjournals.org/content/52/20/5707.full.pdf might your statement "Nonetheless, I think we should abandon this therapeutic path, that the idea is now dead in the water." be a little premature ?-)<br /><br />Carotenoids Up-Regulate Connexin43 Gene Expression Independent of Their Provitamin A or Antioxidant Properties1 Li-Xin Zhang, Robert V. Cooney, and John S. Bertram2 Molecular Oncology Unit, Cancer Research Center of Hawaii. University of Hawaii, Honolulu, Hawaii <br /><br />ABSTRACT<br />Epidemiological evidence and studies in whole animals and cell culture have indicated that carotenoids have cancer chemopreventive action. In mouse C3H10T1/2 cells, this activity is highly correlated with the ability of carotenoids to up-regulate gap junctional intercellular communication. Here, we report that in mouse cells, carotenoids increase the expression of connexM.ì,a gene that encodes a major gap junction protein. This effect appears unrelated to their provitamin A or antioxidant properties, since carotenoids with and without provitamin A activity increased levels of connexin43 mRNA and protein, whereas the antioxidants methyl-bixin and a-tocopherol were inactive. More over, the active carotenoid canthaxanthin did not induce the vitamin A-inducible gene retinoic acid receptor-0. Connexln4i is the first carotenoid-inducible gene described in mammals. By indicating an additional pathway through which carotenoids function, these data provide a mechanistic basis for cancer chemoprevention by carotenoids and may lead to a re-evaluation of carotenoid physiology.David Stockwellhttps://www.blogger.com/profile/13549904139331826915noreply@blogger.comtag:blogger.com,1999:blog-1474751880645498536.post-12459483293156042512013-04-17T18:07:20.465-04:002013-04-17T18:07:20.465-04:00As usual very interesting. I need a lot more unde...As usual very interesting. I need a lot more understanding of statistic which I plan to work on. I do believe that the tendency to trusting "natural products" comes from the same root as the "trusting our own body's evolution" that you talk about. Eating whole foods that have been around for thousands of years or longer makes sense compared to eating recently engineered foods. I don't know that they are healthier but I do know that with every change we make we have unintended consequences. High fructose corn syrup seems to coincide with increased obesity. It seemed like a good idea at the time but now maybe not so much. As far as nutrition in the ICU setting you may be right. Fluid administration in sepsis is important but nutrition may be the opposite. Maybe you could do a study with that opposite hypothesis of anorexia being more beneficial than early supplementation and find out.Anonymoushttps://www.blogger.com/profile/06791654657223028320noreply@blogger.com