tag:blogger.com,1999:blog-1474751880645498536.post9137722956739949205..comments2023-10-10T10:14:36.340-04:00Comments on Medical Evidence Blog: Conjugated Equine Estrogen (CEE) reduces breast cancer AFTER the trial is completed?Scott K. Aberegg, M.D., M.P.H.http://www.blogger.com/profile/17564774546019869201noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-1474751880645498536.post-72527786059002745472011-04-08T12:15:11.669-04:002011-04-08T12:15:11.669-04:00A former colleague e-mailed me these criticisms of...A former colleague e-mailed me these criticisms of the blog post:<br /><br />No “legitimate reason to think some difference based on age strata might make biological sense”…really?<br />How about CEE works for primary prevention (so prevents women from getting same risk as men if you supplement estrogen at the time of menopause) but it doesn’t work for secondary prevention (women aged 60-69 who have been exposed to 10 years of menopause)<br /> <br />One of the biggest criticisms of WHI was that it enrolled lots of women not getting HRT - those who were 10 years post-menopausal – as opposed to perimenopausal women.<br /> <br />What I don’t understand is why they used age strata – rather than time since menopause as the unit of analysis.<br /> <br />I thought you were the one arguing that when mortality is the outcome, any improvement matters if the intervention is cheap and statistical significance be damned….<br />There appears to be a dose-response here<br />Death and CEE group – 50-59y – HR 0.73, 60-69y HR 1.04, 70-79y HR 1.12<br /> <br />What this says to me is that the WHI should have been better designed and not so focused on just meeting recruitment numbers. Why in the hell were they enrolling 70 year olds (22% were 70 or older!) to start with?Scott K. Aberegg, M.D., M.P.H.https://www.blogger.com/profile/17564774546019869201noreply@blogger.comtag:blogger.com,1999:blog-1474751880645498536.post-23644866635697256722011-04-07T17:33:40.421-04:002011-04-07T17:33:40.421-04:00Gail Collins of the NYT is confused about Estrogen...Gail Collins of the NYT is confused about Estrogen now as a result of this study: <br /><br />http://www.nytimes.com/2011/04/07/opinion/07collins.html?src=me&ref=general<br /><br />I directed her to the Medical Evidence Blog to help her understand why she's confused - it's not her fault.Scott K. Aberegg, M.D., M.P.H.https://www.blogger.com/profile/17564774546019869201noreply@blogger.com