Medical Evidence Blog

This is discussion forum for physicians, researchers, and other healthcare professionals interested in the epistemology of medical knowledge, the limitations of the evidence, how clinical trials evidence is generated, disseminated, and incorporated into clinical practice, how the evidence should optimally be incorporated into practice, and what the value of the evidence is to science, individual patients, and society.

Showing posts with label NEJM. Show all posts
Showing posts with label NEJM. Show all posts
Thursday, September 27, 2012

True Believers: Faith and Reason in the Adoption of Evidence

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 In last week's NEJM, in an editorial response to an article demonstrating that physicians, in essence, probability adjust (a la Exp...
2 comments:
Monday, September 21, 2009

The unreliable assymmetric design of the RE-LY trial of Dabigatran: Heads I win, tails you lose

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I'm growing weary of this. I hope it stops. We can adapt the diagram of non-inferiority shenanigans from the Gefitinib trial (see http:/...
8 comments:
Sunday, September 6, 2009

There's no such thing as a free lunch - unless you're running a non-inferiority trial. Gefitinib for pulmonary adenocarcinoma

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A 20% difference in some outcome is either clinically relevant, or it is not. If A is worse than B by 19% and that's NOT clinically rele...
3 comments:
Monday, June 2, 2008

"Off-Label Promotion By Proxy": How the NEJM and Clinical Trials are Used as an Advertising Apparatus. The Case of Aliskiren

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In the print edition of the June 5th NEJM (mine is delivered almost a week early sometimes), readers will see on the front cover the lead ar...
10 comments:
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Scott K. Aberegg, M.D., M.P.H.
Professor of Medicine, University of Utah. Former affiliations: Outside Hospital x 7.5 years; Assistant Professor, The Ohio State University; Fellowship & MPH: Johns Hopkins Hospital & Bloomberg School of Public Health, Baltimore, MD; Residency: The University of New Mexico Health Sciences Center; MD: The Ohio State University; BA, Spanish: Miami University, Ohio. All views are my own with NO institutional endorsement.
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