Medical Evidence Blog

This is discussion forum for physicians, researchers, and other healthcare professionals interested in the epistemology of medical knowledge, the limitations of the evidence, how clinical trials evidence is generated, disseminated, and incorporated into clinical practice, how the evidence should optimally be incorporated into practice, and what the value of the evidence is to science, individual patients, and society.

Showing posts with label RCT. Show all posts
Showing posts with label RCT. Show all posts
Thursday, January 5, 2017

RCT Autopsy: The Differential Diagnosis of a Negative Trial

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At many institutions, Journal Clubs meet to dissect a trial after its results are published to look for flaws, biases, shortcomings, limi...
2 comments:
Saturday, June 11, 2016

Non-inferiority Trials Are Inherently Biased: Here's Why

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Debut VideoCast for the Medical Evidence Blog, explaining non-inferiority trial design and exposing its inherent biases: In this relate...
Wednesday, October 7, 2015

Early Mobility in the ICU: The Trial That Should Not Be

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I learned via twitter yesterday that momentum is building to conduct a trial of early mobility in critically ill patients.  While I great...
Saturday, January 17, 2015

Clinical Trialists Should Use Economies of Scale to Maximize Profits of Large RCTs

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The lever is a powerful tool I am writing (very slowly) a review article about ionized calcium in the ICU - should it be measured, and ...
1 comment:
Sunday, January 27, 2013

Therapeutic Agnosticism: Stochastic Dominance of the Null Hypothesis

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Here are some more thoughts on the epistemology of medical science and practice that were stimulated by reading three articles this week ...
2 comments:
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Scott K. Aberegg, M.D., M.P.H.
Professor of Medicine, University of Utah. Former affiliations: Outside Hospital x 7.5 years; Assistant Professor, The Ohio State University; Fellowship & MPH: Johns Hopkins Hospital & Bloomberg School of Public Health, Baltimore, MD; Residency: The University of New Mexico Health Sciences Center; MD: The Ohio State University; BA, Spanish: Miami University, Ohio. All views are my own with NO institutional endorsement.
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