Medical Evidence Blog

This is discussion forum for physicians, researchers, and other healthcare professionals interested in the epistemology of medical knowledge, the limitations of the evidence, how clinical trials evidence is generated, disseminated, and incorporated into clinical practice, how the evidence should optimally be incorporated into practice, and what the value of the evidence is to science, individual patients, and society.

Showing posts with label delta. Show all posts
Showing posts with label delta. Show all posts
Thursday, December 5, 2019

Noninferiority Trials of Reduced Intensity Therapies: SCORAD trial of Radiotherapy for Spinal Metastases

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No mets here just my PTX A trial in JAMA this week by Hoskin et al (the SCORAD trial) compared two different intensities of radiother...
Thursday, September 8, 2016

Hiding the Evidence in Plain Sight: One-sided Confidence Intervals and Noninferiority Trials

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In the last post, I linked a video podcast of my explaining non-inferiority trials and their inherent biases.  In this videocast, I revisit...
3 comments:
Saturday, June 11, 2016

Non-inferiority Trials Are Inherently Biased: Here's Why

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Debut VideoCast for the Medical Evidence Blog, explaining non-inferiority trial design and exposing its inherent biases: In this relate...
Monday, May 20, 2013

It All Hinges on the Premises: Prophylactic Platelet Transfusion in Hematologic Malignancy

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A quick update before I proceed with the current post:   The Institute of Medicine has met and they agree with me that sodium restricti...
1 comment:
Wednesday, December 16, 2009

Dabigatran and Dabigscam of non-inferiority trials, pre-specified margins of non-inferiority, and relative risks

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Anyone who thought, based on the evidence outlined in the last post on this blog, that dabigatran was going to be a "superior" rep...
1 comment:
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Scott K. Aberegg, M.D., M.P.H.
Professor of Medicine, University of Utah. Former affiliations: Outside Hospital x 7.5 years; Assistant Professor, The Ohio State University; Fellowship & MPH: Johns Hopkins Hospital & Bloomberg School of Public Health, Baltimore, MD; Residency: The University of New Mexico Health Sciences Center; MD: The Ohio State University; BA, Spanish: Miami University, Ohio. All views are my own with NO institutional endorsement.
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