Medical Evidence Blog

This is discussion forum for physicians, researchers, and other healthcare professionals interested in the epistemology of medical knowledge, the limitations of the evidence, how clinical trials evidence is generated, disseminated, and incorporated into clinical practice, how the evidence should optimally be incorporated into practice, and what the value of the evidence is to science, individual patients, and society.

Showing posts with label margin of non-inferiority. Show all posts
Showing posts with label margin of non-inferiority. Show all posts
Monday, May 20, 2013

It All Hinges on the Premises: Prophylactic Platelet Transfusion in Hematologic Malignancy

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A quick update before I proceed with the current post:   The Institute of Medicine has met and they agree with me that sodium restricti...
1 comment:
Friday, August 20, 2010

Heads I Win, Tails it's a Draw: Rituximab, Cyclophosphamide, and Revising CONSORT

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The recent article by Stone et al in the NEJM (see: http://www.nejm.org/doi/full/10.1056/NEJMoa0909905 ), which appears to [mostly] conform...
Wednesday, December 16, 2009

Dabigatran and Dabigscam of non-inferiority trials, pre-specified margins of non-inferiority, and relative risks

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Anyone who thought, based on the evidence outlined in the last post on this blog, that dabigatran was going to be a "superior" rep...
1 comment:
Monday, September 21, 2009

The unreliable assymmetric design of the RE-LY trial of Dabigatran: Heads I win, tails you lose

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I'm growing weary of this. I hope it stops. We can adapt the diagram of non-inferiority shenanigans from the Gefitinib trial (see http:/...
8 comments:
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Scott K. Aberegg, M.D., M.P.H.
Professor of Medicine, University of Utah. Former affiliations: Outside Hospital x 7.5 years; Assistant Professor, The Ohio State University; Fellowship & MPH: Johns Hopkins Hospital & Bloomberg School of Public Health, Baltimore, MD; Residency: The University of New Mexico Health Sciences Center; MD: The Ohio State University; BA, Spanish: Miami University, Ohio. All views are my own with NO institutional endorsement.
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