Medical Evidence Blog

This is discussion forum for physicians, researchers, and other healthcare professionals interested in the epistemology of medical knowledge, the limitations of the evidence, how clinical trials evidence is generated, disseminated, and incorporated into clinical practice, how the evidence should optimally be incorporated into practice, and what the value of the evidence is to science, individual patients, and society.

Showing posts with label noninferiority. Show all posts
Showing posts with label noninferiority. Show all posts
Thursday, December 5, 2019

Noninferiority Trials of Reduced Intensity Therapies: SCORAD trial of Radiotherapy for Spinal Metastases

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No mets here just my PTX A trial in JAMA this week by Hoskin et al (the SCORAD trial) compared two different intensities of radiother...
Sunday, April 21, 2019

A Finding of Noninferiority Does Not Show Efficacy - It Shows Noninferiority (of short course rifampin for MDR-TB)

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An image of two separated curves from Mayo's book SIST Published in the March 28th, 2019 issue of the NEJM is the STREAM trial of a...
Thursday, February 15, 2018

Ruling Out PE in the ED: Critical Analysis of the PROPER Trial

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This post is going to be an in-depth "journal club" style analysis of the PROPER trial. In this week's JAMA, Freund et ...
Tuesday, April 4, 2017

Tipping the Scales of Noninferiority: Abbott's "Emboshield and Xact Carotid Stent System"

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I just stumbled across this and think it's worth musing over it a bit.  The recently published ACT I trial by Rosenfield et al  is a ...
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Scott K. Aberegg, M.D., M.P.H.
Professor of Medicine, University of Utah. Former affiliations: Outside Hospital x 7.5 years; Assistant Professor, The Ohio State University; Fellowship & MPH: Johns Hopkins Hospital & Bloomberg School of Public Health, Baltimore, MD; Residency: The University of New Mexico Health Sciences Center; MD: The Ohio State University; BA, Spanish: Miami University, Ohio. All views are my own with NO institutional endorsement.
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