- The EPANIC trial (NEJM, August 11, 2011) showed that late (and less) nutrition was superior in critically ill adults
- The OMEGA study (JAMA, October 12, 2011) showed that provision of supplemental n-3 fatty acids, γ-linolenic acid, and antioxidants in patients with ARDS caused increased time on the ventilator and a strong trend towards increased mortality
- The EDEN study (JAMA,February 22/29, 2012) showed that delaying full feeding for the first week of illness had basically no effect on outcomes.
- A post-hoc analysis of the EPANIC data (AJRCCM, February 1, 2013) concluded that "no dose or type of macronutrient was found to be associated with improved outcome." The editorialist opines that we are pandering to gluttony in the ICU. I am inclined to agree with him. If less isn't more, it sure looks like it's the same as more.
[Addendum 6/9/2013: Here's a great JAMA piece by Paul Offit about the silliness of alternative and complementary medicine.]